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Ian S Zagon Selected Research

Opioid Peptides (Opioid Peptide)

3/2015Improved clinical behavior of established relapsing-remitting experimental autoimmune encephalomyelitis following treatment with endogenous opioids: implications for the treatment of multiple sclerosis.
10/2011Topical treatment with the opioid antagonist naltrexone facilitates closure of full-thickness wounds in diabetic rats.
7/2011Therapy with the opioid antagonist naltrexone promotes mucosal healing in active Crohn's disease: a randomized placebo-controlled trial.
7/2011Low-dose naltrexone suppresses ovarian cancer and exhibits enhanced inhibition in combination with cisplatin.
1/2011B lymphocyte proliferation is suppressed by the opioid growth factor-opioid growth factor receptor axis: Implication for the treatment of autoimmune diseases.
11/2009Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis: a new paradigm for the treatment of multiple sclerosis.
6/2004Opioid growth factor (OGF) inhibits anchorage-independent growth in human cancer cells.

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Ian S Zagon Research Topics

Disease

35Neoplasms (Cancer)
10/2015 - 02/2002
17Multiple Sclerosis
05/2021 - 11/2009
15Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
01/2022 - 11/2009
12Squamous Cell Carcinoma of Head and Neck
04/2012 - 04/2003
11Wounds and Injuries (Trauma)
01/2021 - 05/2003
11Pancreatic Neoplasms (Pancreatic Cancer)
03/2014 - 12/2002
8Dry Eye Syndromes (Dry Eye Syndrome)
10/2021 - 11/2009
8Ovarian Neoplasms (Ovarian Cancer)
03/2014 - 06/2009
8Necrosis
05/2013 - 04/2003
6Type 1 Diabetes Mellitus (Autoimmune Diabetes)
07/2021 - 11/2009
6Autoimmune Diseases (Autoimmune Disease)
12/2018 - 01/2011
5Corneal Injuries
03/2014 - 11/2006
4Type 2 Diabetes Mellitus (MODY)
01/2021 - 09/2012
4Crohn Disease (Crohn's Disease)
01/2017 - 04/2007
3Inflammation (Inflammations)
01/2022 - 04/2008
3Diabetes Complications
01/2021 - 10/2015
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
09/2010 - 03/2007
3Colonic Neoplasms (Colon Cancer)
08/2006 - 04/2003
2Body Weight (Weight, Body)
07/2021 - 07/2005
2Foot Ulcer
01/2021 - 09/2017
2Hyperglycemia
01/2021 - 11/2019
2Disease Progression
12/2020 - 01/2018
2Encephalomyelitis (Myeloencephalitis)
09/2017 - 11/2009
2Fatigue
01/2017 - 01/2016
2Infections
06/2014 - 04/2008
2Triple Negative Breast Neoplasms
03/2014 - 06/2013
2Persistent Infection
10/2013 - 07/2013
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
07/2011 - 04/2007
2Carcinogenesis
07/2011 - 08/2006
2Diabetes Mellitus
11/2009 - 08/2007
2Adenocarcinoma
11/2005 - 04/2003
1Nervous System Diseases (Neurological Disorders)
12/2020
1Chronic Pain
12/2018
1Diabetic Foot
09/2017
1Fibromyalgia (Fibrositis)
01/2017
1Relapsing-Remitting Multiple Sclerosis
01/2016
1Pain (Aches)
10/2015
1Demyelinating Diseases (Demyelinating Disease)
03/2015

Drug/Important Bio-Agent (IBA)

57Opioid Analgesics (Opioids)IBA
01/2022 - 02/2002
46Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2022 - 02/2002
34methionine-enkephalin receptorIBA
10/2021 - 04/2003
33Naltrexone (ReVia)FDA LinkGeneric
01/2022 - 04/2003
22EnkephalinsIBA
01/2021 - 02/2002
17Narcotic Antagonists (Opioid Antagonists)IBA
10/2021 - 04/2003
16DNA (Deoxyribonucleic Acid)IBA
09/2017 - 11/2005
9Peptides (Polypeptides)IBA
01/2021 - 02/2002
9Biological ProductsIBA
03/2014 - 11/2008
8Opioid Receptors (Opioid Receptor)IBA
01/2017 - 11/2009
7Streptozocin (Streptozotocin)FDA Link
07/2021 - 08/2007
7Opioid Peptides (Opioid Peptide)IBA
03/2015 - 06/2004
6Proteins (Proteins, Gene)FDA Link
09/2013 - 12/2002
5Biomarkers (Surrogate Marker)IBA
05/2021 - 01/2017
5Paclitaxel (Taxol)FDA LinkGeneric
07/2015 - 03/2005
5Phosphotransferases (Kinase)IBA
07/2015 - 06/2006
4CyclinsIBA
06/2013 - 06/2006
4Complementary DNA (cDNA)IBA
10/2008 - 12/2002
4Messenger RNA (mRNA)IBA
08/2006 - 12/2002
3Insulin (Novolin)FDA Link
07/2021 - 08/2007
3GemcitabineFDA Link
07/2015 - 11/2005
3Bromodeoxyuridine (BrdU)IBA
06/2014 - 08/2006
3Imiquimod (Aldara)FDA LinkGeneric
04/2012 - 08/2008
3Pharmaceutical PreparationsIBA
11/2009 - 07/2005
3Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)IBA
12/2007 - 04/2003
3Dynorphins (Dynorphin)IBA
12/2007 - 04/2003
3endomorphin 1IBA
12/2007 - 04/2003
3Morphine (MS Contin)FDA LinkGeneric
12/2007 - 04/2003
3beta-Endorphin (Endorphin, beta)IBA
12/2007 - 04/2003
3CCK-C receptorIBA
11/2004 - 12/2002
2Glucose (Dextrose)FDA LinkGeneric
07/2021 - 11/2009
2CytokinesIBA
01/2018 - 09/2017
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2017 - 07/2013
2Glycoproteins (Glycoprotein)IBA
09/2017 - 04/2015
2NeuropeptidesIBA
03/2014 - 09/2012
2CollagenIBA
10/2013 - 12/2007
2RNA (Ribonucleic Acid)IBA
05/2013 - 12/2002
2Cyclin-Dependent Kinases (cdk Proteins)IBA
10/2009 - 11/2007
2Naloxone (Narcan)FDA LinkGeneric
10/2005 - 04/2003
2Cholecystokinin B ReceptorIBA
11/2004 - 12/2002
2Cholecystokinin (Pancreozymin)IBA
11/2004 - 12/2002
2GastrinsIBA
03/2004 - 12/2002
1Blood Glucose (Blood Sugar)IBA
07/2021
1EndorphinsIBA
05/2021
1Indicators and Reagents (Reagents)IBA
01/2021
1OsteocalcinIBA
11/2019
1Interleukin-10 (Interleukin 10)IBA
01/2018
1Interleukin-6 (Interleukin 6)IBA
01/2018
1Dihydrotachysterol (AT 10)IBA
01/2018
1Becaplermin (PDGF-BB)FDA Link
09/2017
1myelin proteolipid protein (139-151)IBA
01/2016
1AntigensIBA
01/2016
1Opiate AlkaloidsIBA
10/2015
1Therapeutic UsesIBA
07/2015
1Fluorouracil (Carac)FDA LinkGeneric
03/2014
1Fluorescein (Funduscein)FDA LinkGeneric
03/2014
1Matrix Metalloproteinases (MMPs)IBA
10/2013

Therapy/Procedure

20Therapeutics
01/2021 - 03/2004
7Biological Therapy
07/2015 - 07/2005
6Surgical Amputation (Amputations)
01/2021 - 10/2011
6Drug Therapy (Chemotherapy)
03/2014 - 07/2005
4Injections
12/2020 - 01/2004